Casual players will always be those at the back of the games curve. They are the last to reach max level, they are the last to down certain bosses and, most importantly, they are the ones that are more likely to purchase their items rather than go out and farm for them. A large amount of your daily sales will be going to the casual player who just wants to be stronger for their nightly endeavors. It is because of this that the subscription model for Guild Wars 2 is really well suited for those of us looking to sell our wares and such.
Just like inother games the idea is to get your disciplines (Professions) maxed out and start obtaining the rarest recipes in the game. This is so you can supply the players who are working on the latest content. Guild Wars 2 is the exact same way. Even Guild Wars 2 will have those hardcore players that blaze through content and spend vicariously. You certainly want to be there to suppy those players; however, they aren't going to be your biggest market. Not by a long shot. What I am saying is that the game will have more casual players. This is dui in part to the fact that they don't have a reason that forces them to play. They don't have to feel like they are getting their moneys worth each month. That translates to people leveling slower and the markets for that gear being around much longer. Pair that with the fact that all servers share a single economy and Guild Wars 2 seems like it was almost designed to make incredible amounts of profit.
Since the first post on this site I have stressed the importance of getting out in front of your competition. You can do this by leveling up two of your most important disciplines early and efficiently. This whole post just further validates the reasoning behind this. If you've got the potential to lock large portion of a globally shared market down, and sit on it, you could have months of prosperity just crafting the most simplistic items. Casual players are going to be your goldmine! The key is to get into that mine as soon as possible and stay there as long as you can.